The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues

Protein Sci. 1996 Jul;5(7):1421-5. doi: 10.1002/pro.5560050720.


A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacteria / enzymology*
  • Humans
  • Molecular Sequence Data
  • Phosphoprotein Phosphatases / genetics*
  • Phylogeny
  • Protein Phosphatase 2
  • Protein Phosphatase 2C
  • Saccharomyces cerevisiae Proteins*


  • Saccharomyces cerevisiae Proteins
  • PPM1A protein, human
  • PPM1B protein, human
  • PPM1G protein, human
  • PTC1 protein, S cerevisiae
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2
  • Protein Phosphatase 2C