Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 31 (7), 665-70

Secretion of the Incretin Hormones Glucagon-Like peptide-1 and Gastric Inhibitory Polypeptide Correlates With Insulin Secretion in Normal Man Throughout the Day

Affiliations

Secretion of the Incretin Hormones Glucagon-Like peptide-1 and Gastric Inhibitory Polypeptide Correlates With Insulin Secretion in Normal Man Throughout the Day

C Orskov et al. Scand J Gastroenterol.

Abstract

Background: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.

Methods: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.

Results: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).

Conclusions: These results support the notion that GLP-1 and GIP are important incretin hormones.

Similar articles

See all similar articles

Cited by 47 articles

See all "Cited by" articles

Publication types

Feedback