Modification of flower colour via manipulation of P450 gene expression in transgenic plants

Drug Metabol Drug Interact. 1995;12(3-4):359-68. doi: 10.1515/dmdi.1995.12.3-4.359.


Unlike animals, which synthesise cytochrome P450 enzymes mostly for the degradation of xenobiotics, plants have evolved a large number of different P450 enzymes for the synthesis of secondary metabolites. Probably the most conspicuous of these secondary metabolites are anthocyanins, which are important flower pigments. The types of anthocyanins synthesised in plants are controlled by the cytochrome P450 enzymes flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase. Cloning of flavonoid 3',5'-hydroxylase genes has enabled the manipulation of anthocyanin synthesis in transgenic plants and enabled the production of novel pigments and flower colours.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Color*
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome P-450 Enzyme System / genetics*
  • Flavonoids / biosynthesis*
  • Flavonoids / genetics
  • Gene Expression Regulation, Plant / drug effects
  • Gene Expression Regulation, Plant / physiology*
  • Genetic Engineering
  • Molecular Sequence Data
  • Plants, Genetically Modified / enzymology*
  • Plants, Genetically Modified / genetics*


  • Flavonoids
  • Cytochrome P-450 Enzyme System