Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse

Jpn J Pharmacol. 1996 Jan;70(1):85-8. doi: 10.1254/jjp.70.85.


Mice were given the extract of cultured Cordyceps sinensis (Cs) (200 mg/kg daily, p.o.) for 3 weeks. In vivo phosphorus-31 nuclear magnetic resonance (NMR) spectra of the liver were acquired at weekly intervals using a surface coil. From 1 to 3 weeks, a consistent increase in the ATP/inorganic phosphate ratio, which represents the high energy state, was observed in the Cs extract-treated mice. The intracellular pH of the Cs extract-treated mice was not significantly different from that of the control mice. No steatosis, necrosis, inflammation or fibrosis were observed in the liver specimens from Cs extract-treated mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Drugs, Chinese Herbal / pharmacology*
  • Energy Metabolism*
  • Hydrogen-Ion Concentration
  • Hypocreales*
  • Liver / metabolism*
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Mice, Inbred Strains
  • Phosphates / metabolism
  • Phosphorus


  • Drugs, Chinese Herbal
  • Phosphates
  • Phosphorus
  • Adenosine Triphosphate