Orbital complications of sinusitis in the aspirin triad syndrome

Laryngoscope. 1996 Sep;106(9 Pt 1):1103-7. doi: 10.1097/00005537-199609000-00012.


Orbital complications are uncommon in adult sinusitis. In contrast, the sinusitis of the aspirin triad syndrome is often fulminate, expansive, and recurrent, and complications may be more frequent. Of 81 patients with aspirin triad who were treated surgically, 7 patients (8.6%) had orbital complications, including sinus mucoceles in 3 patients, lacrimal gland extension in 2 patients, inflammatory orbital mass in 1 patient, and proptosis from expansile sinonasal polyposis in 1 patient. All complications manifested within 2 years of prior surgery. Two patients suffered blindness. In a group of 120 consecutively treated sinus surgery patients without aspirin triad syndrome (51 of whom were followed for more than 2 years), no patient manifested nonoperative orbital complications. The results of this study suggest that aspirin triad patients are at significant risk for orbital complications and therefore should have long-term follow-up with aggressive treatment of persistent disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aspirin / adverse effects*
  • Asthma / metabolism*
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Orbital Diseases / etiology*
  • Retrospective Studies
  • Sinusitis / complications*
  • Sinusitis / diagnostic imaging
  • Syndrome
  • Tomography, X-Ray Computed


  • Aspirin