Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tü 4018. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 1996 Aug;49(8):758-64. doi: 10.7164/antibiotics.49.758.

Abstract

The kanchanamycins, a group of novel 36-membered polyol macrolide antibiotics were detected in the culture filtrate and mycelium of Streptomyces olivaceus Tü 4018 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibacterial and antifungal activities, and are especially effective against Pseudomonas fluorescens. Besides the kanchanamycin complex, strain Tü 4018 produces the 42-membered macrolactones, oasomycin A and desertomycin A, as well as tryptophan-dehydrobutyrine diketopiperazine and daidzein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Chromatography, High Pressure Liquid
  • Fermentation*
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Macrolides
  • Streptomyces / classification
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Lactones
  • Macrolides
  • kanchanamycin A
  • kanchanamycin C
  • kanchanamycin D