Risk factors for Pneumocystis carinii pneumonia in patients with polymyositis/dermatomyositis or systemic lupus erythematosus

J Rheumatol. 1996 Jul;23(7):1186-8.


Objective: To investigate risk factors for Pneumocystis carinii pneumonia (PCP) in patients with systemic lupus erythematosus (SLE) and polymyositis/dermatomyositis (PM/DM).

Methods: The subjects were 75 patients hospitalized because of SLE or PM/DM who were administered corticosteroids 40 mg/day or above as prednisolone. The relationship between clinical symptoms of SLE and PM/DM and the occurrence of PCP was evaluated.

Results: Seven patients (9.3%) developed PCP and 3 died. Interstitial pulmonary fibrosis was observed in all 7 patients who developed PCP, and its incidence was significantly higher (p < 0.001) than in those who did not develop PCP (6/68). The incidence of PCP in patients with SLE was 1.7%, but that of patients with PM/DM was 37.5%. The peripheral blood lymphocyte count was 1052.7/microliters in patients who developed PCP, which was significantly lower (p < 0.01) than 1841.6/microliters in patients who did not develop PCP.

Conclusion: A low peripheral lymphocyte count and interstitial pulmonary fibrosis were considered risk factors for PCP in patients administered corticosteroids for SLE or PM/DM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Central Nervous System Diseases / etiology
  • Central Nervous System Diseases / microbiology
  • Dermatomyositis / complications
  • Dermatomyositis / epidemiology*
  • Dermatomyositis / microbiology
  • Female
  • Humans
  • Incidence
  • Kidney Diseases / etiology
  • Kidney Diseases / microbiology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / epidemiology*
  • Lupus Erythematosus, Systemic / microbiology
  • Male
  • Middle Aged
  • Opportunistic Infections / epidemiology
  • Pneumonia, Pneumocystis / epidemiology*
  • Polymyositis / complications
  • Polymyositis / epidemiology*
  • Polymyositis / microbiology
  • Risk Factors