Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats

J Ethnopharmacol. 1995 Dec 15;49(3):119-26. doi: 10.1016/0378-8741(95)01291-5.


Seeds of Apium graveolens L. (Apiaceae) and Hygrophila auriculata (K. Schum.) Heine (Syn. Astercantha auriculata Nees, Acanthaceae) are used in Indian systems of medicine for the treatment of liver ailments. The antihepatotoxic effect of methanolic extracts of the seeds of these two plants was studied on rat liver damage induced by a single dose of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.) by monitoring several liver function tests, viz. serum transaminases (SGOT and SGPT), alkaline phosphatase, sorbitol dehydrogenase, glutamate dehydrogenase and bilirubin in serum. Furthermore, hepatic tissues were processed for assay of triglycerides and histopathological alterations simultaneously. A significant hepatoprotective activity of the methanolic extract of the seeds of both the plants was reported.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / toxicity*
  • Animals
  • Chemical and Drug Induced Liver Injury
  • Drug Interactions
  • Female
  • India
  • Liver / drug effects
  • Liver / pathology
  • Liver Diseases / prevention & control*
  • Liver Function Tests
  • Male
  • Medicine, Ayurvedic
  • Plant Extracts / pharmacology
  • Plants, Medicinal*
  • Rats
  • Thioacetamide / toxicity*


  • Plant Extracts
  • Thioacetamide
  • Acetaminophen