The staphylococcal insertion sequence IS257 is active

Plasmid. 1995 Nov;34(3):198-205. doi: 10.1006/plas.1995.0005.


The plasmid pJ3356 confers high-level mupirocin resistance on a strain of Staphylococcus aureus isolated from a hospital. The plasmid also carries two copies of IS257. Recombination of an IS257-containing plasmid conferring erythromycin resistance, pOX7-IS, into either of the IS257s of pJ3356 has been observed. The co-integration of pJ3356 and a small plasmid, pOX7, is also reported and involves duplication of one of the IS257s from pJ3356 together with 8 bp of pOX7 at the site of integration. Thus IS257 has been shown to be an active mobile genetic element.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Primers
  • DNA Transposable Elements / genetics*
  • DNA, Bacterial / genetics*
  • Gene Expression Regulation, Bacterial / genetics*
  • Molecular Sequence Data
  • Plasmids / genetics
  • Staphylococcus aureus / genetics*


  • DNA Primers
  • DNA Transposable Elements
  • DNA, Bacterial