New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease

Pediatr Res. 1996 Jan;39(1):117-9. doi: 10.1203/00006450-199601000-00017.


We measured the plasma concentration of allantoin, an oxidation product of uric acid and an "in vivo" marker of free radical generation, within 24-48 h after birth in 10 premature infants who subsequently developed chronic lung disease (CLD) and 9 infants without CLD (non-CLD). The plasma allantoin level (mean +/- SD, 25.9 +/- 9.8 microM for CLD versus 11.0 +/- 5.7 microM for non-CLD, p < 0.01) and the allantoin/urate ratio (5.8 +/- 2.0% for CLD infants versus 2.4 +/- 0.9% for non-CLD infants, p < 0.01) were significantly higher in the CLD group than those in the non-CLD group. These observations suggest the possible involvement of oxygen radicals in triggering CLD. In addition, the plasma allantoin concentration and the allantoin/urate ratio may be useful early predictors of the development of CLD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allantoin / blood*
  • Chronic Disease
  • Female
  • Free Radicals
  • Humans
  • Infant, Newborn
  • Lung Diseases / etiology*
  • Male
  • Oxygen
  • Uric Acid / blood*


  • Free Radicals
  • Uric Acid
  • Allantoin
  • Oxygen