Regional localization of two MRX genes to Xq28 (MRX28) and to Xp11.4-Xp22.12 (MRX33)

Am J Med Genet. 1996 Jul 12;64(1):125-30. doi: 10.1002/(SICI)1096-8628(19960712)64:1<125::AID-AJMG21>3.0.CO;2-O.


Two genes responsible for a nonspecific form of X-linked mental retardation (MRX28 and MRX33) were localized by linkage analysis with 40 highly polymorphic DNA markers situated along the entire the X chromosome. In family 1, the gene could be mapped within a 14-cM interval at Xq28, distal to the recombining marker DXS1113 (MRX28). The maximum LOD score was 2.75, with DXS52 at phi = .0. In family 2, the gene was localized within a 30-cM interval at Xp11.4-22.12 between the recombining markers DXS365 and MAOB, including the DMD gene (MRX33). Maximum LOD scores of 2.82 were obtained with markers DMD-STR49, DMD-DysII, CYBB, and DXS1068.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Chromosome Mapping*
  • DNA
  • Female
  • Genetic Carrier Screening
  • Genetic Linkage*
  • Humans
  • Infant
  • Intellectual Disability / genetics*
  • Lod Score
  • Male
  • Pedigree
  • X Chromosome*


  • DNA