Chronic neutrophil leukaemia in adolescence and young adulthood

Br J Haematol. 1996 Sep;94(4):628-30. doi: 10.1046/j.1365-2141.1996.7082329.x.


Chronic neutrophil leukaemia (CNL) is a rare myeloproliferative disorder predominantly reported in elderly patients. We present a 15-year-old girl and a 25-year-old male with CNL. Clonal cytogenetic abnormalities were detected in both patients. One showed trisomy 21 evolving into tetrasomy 21. The second patient showed a unique chromosome aberration during blast crisis: t(2;2)(q32;p24). Both patients were successfully treated with allogeneic bone marrow transplantation (BMT). CNL should also be considered as a differential diagnosis in adolescence and young adulthood. BMT represents a potentially curative treatment option in such patients.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Bone Marrow Transplantation
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 21*
  • Female
  • Humans
  • Karyotyping
  • Leukemia, Neutrophilic, Chronic / genetics*
  • Leukemia, Neutrophilic, Chronic / therapy
  • Male
  • Trisomy