Interpreting genetic variability: the effects of shared evolutionary history

Ciba Found Symp. 1996;197:25-40; discussion 40-50. doi: 10.1002/9780470514887.ch3.

Abstract

Data from different individuals at a single locus are positively correlated because of the shared genealogy of the sampled genes. This paper illustrates the qualitative effects on genealogical trees of assumptions about population demography, and it considers the consequences for genetic variability. An understanding of these effects is invaluable in the interpretation of data and for inferences about population history. In contrast, traditional genetic measures of diversity and approximation methods do not seem well suited for addressing the problem.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Genetic Variation*
  • Genome, Human*
  • Humans
  • Phylogeny