Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)

Microb Pathog. 1996 Jul;21(1):17-22. doi: 10.1006/mpat.1996.0038.

Abstract

Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJ Xid mice with PsaA using either complete Freund's or TiterMax adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD50. The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.

MeSH terms

  • Adhesins, Bacterial
  • Animals
  • Antibodies, Bacterial / analysis
  • Bacterial Proteins / immunology*
  • Blotting, Western
  • Lipoproteins*
  • Membrane Transport Proteins*
  • Mice
  • Mice, Inbred CBA
  • Photosystem I Protein Complex*
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / prevention & control*
  • Specific Pathogen-Free Organisms
  • Streptococcus pneumoniae / immunology*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / immunology*

Substances

  • Adhesins, Bacterial
  • Antibodies, Bacterial
  • Bacterial Proteins
  • Lipoproteins
  • Membrane Transport Proteins
  • Photosystem I Protein Complex
  • PsaA protein, Streptococcus
  • Vaccines, Synthetic
  • pneumococcal surface protein A