Immune globulin treatment in intractable epilepsy of childhood

Turk J Pediatr. Jul-Sep 1996;38(3):301-5.


Six children suffering from epilepsy refractory to conventional anti-convulsive therapy were treated with high-dose intravenous immune globulin (IVIG) (200 mg/kg three times per week, repeated after three weeks). In four children clinical and EEG findings markedly improved, while a partial response was noted in the other cases. These results suggest that high-dose intravenous immune globulin may have a beneficial effect in the treatment of intractable epilepsy.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsy, Generalized / immunology
  • Epilepsy, Generalized / physiopathology
  • Epilepsy, Generalized / therapy*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / pharmacology
  • Immunoglobulins, Intravenous / therapeutic use*
  • Male
  • Turkey


  • Immunoglobulins, Intravenous