Benzodiazepine types in high versus therapeutic dose dependence

Addiction. 1996 Aug;91(8):1179-86. doi: 10.1046/j.1360-0443.1996.91811799.x.


Two types of benzodiazepine dependence have been described: high vs. therapeutic dose dependence. So far, no systematic research has been conducted regarding the frequency with which the various benzodiazepines are represented in one type or the other. In this study, 153 dependent patients using 14 different benzodiazepines were evaluated to assess the prevalence of their use among high vs. therapeutic dose dependents. Triazolam was the single drug most frequently used by high-dose dependents, followed by Lorazepam. No significant differences were found among benzodiazepines regarding their use by therapeutic dose dependents. Our data shows that pharmacokinetic and pharmacodynamic factors appear to be related to the frequency with which the different benzodiazepines are used by high and therapeutic dose dependents.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Anxiety Agents* / administration & dosage
  • Cross-Sectional Studies
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Spain / epidemiology
  • Substance-Related Disorders / classification*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / rehabilitation
  • Triazolam / administration & dosage


  • Anti-Anxiety Agents
  • Triazolam