Immunological determinants of disease caused by respiratory syncytial virus

Trends Microbiol. 1996 Jul;4(7):290-3. doi: 10.1016/0966-842x(96)10032-9.


Various disease syndromes caused by respiratory syncytial virus (RSV) may have a common mechanism of pathogenesis mediated by cytokines produced by type 2 T helper cells. The nature of the immune response to RSV is determined by the pattern of cytokines produced sequentially by many different cell types. Vaccination can influence the types of cytokine produced by selectively activating T cell subpopulations and inducing an immune response that clears the virus with minimal immunopathology.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cattle
  • Cytokines / metabolism
  • Mice
  • Respiratory Syncytial Virus Infections / immunology*
  • Respiratory Syncytial Virus, Human / pathogenicity*
  • T-Lymphocytes, Helper-Inducer / metabolism*
  • Time Factors
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / adverse effects*


  • Cytokines
  • Viral Vaccines