Expression of cyclin D1 and p53 protein in various malignant skin tumors

Dermatology. 1996;192(2):94-8. doi: 10.1159/000246329.


Background: Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors.

Objectives: We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein.

Methods: Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors.

Results: Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein.

Conclusion: Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.

MeSH terms

  • Biomarkers / analysis
  • Biopsy, Needle
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Cyclin D1
  • Cyclins / analysis*
  • Histiocytoma, Benign Fibrous / metabolism*
  • Histiocytoma, Benign Fibrous / pathology
  • Humans
  • Immunohistochemistry
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Oncogene Proteins / analysis*
  • Sensitivity and Specificity
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Tumor Suppressor Protein p53 / analysis*


  • Biomarkers
  • Cyclins
  • Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Cyclin D1