Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis

Pancreas. 1996 Apr;12(3):294-7. doi: 10.1097/00006676-199604000-00013.


Acute pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) occurs in 3-18% of patients undergoing either diagnostic or therapeutic ERCP. We prospectively measured urinary trypsinogen activation peptides (TAP) by an automated anti-TAP enzyme-linked immunoassay among 107 patients 4 h after ERCP to determine whether this measurement helps in the early diagnosis of ERCP-induced pancreatitis. Pancreatitis was documented in 10 of 107 patients (9.3%). All episodes were graded as mild. Urinary TAP was not significantly increased. We conclude that measurement of urinary TAP 4 h after ERCP is not helpful in documenting mild ERCP-induced acute pancreatitis.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides / urine*
  • Pancreatitis / diagnosis*
  • Pancreatitis / urine
  • Prospective Studies
  • Trypsinogen*


  • Oligopeptides
  • trypsinogen activation peptide
  • Trypsinogen