Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC/BCR/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists

Eur J Clin Chem Clin Biochem. 1996 Jun;34(6):517-20.


The release in 1993 of a new reference material for serum proteins, CRM 470/RPPHS 5 has given rise to a great improvement in the between-laboratory variability of serum protein measurements worldwide. Conversion to the new reference material results in significant changes in reference values for some proteins. The establishment of new reference ranges will take a considerable time, and in the interim several professional societies and diagnostic companies have agreed to use consensus reference ranges based on studies already undertaken.

Publication types

  • Consensus Development Conference
  • Guideline
  • Review

MeSH terms

  • Blood Proteins / analysis*
  • Drug Industry
  • Humans
  • Reagent Kits, Diagnostic / standards*
  • Reference Standards
  • Reference Values
  • Societies, Scientific


  • Blood Proteins
  • Reagent Kits, Diagnostic