Exaggerated platelet reactivity in major depression

Am J Psychiatry. 1996 Oct;153(10):1313-7. doi: 10.1176/ajp.153.10.1313.


Objective: This study investigated whether depressed patients exhibit exaggerated platelet reactivity.

Method: In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge.

Results: The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12.

Conclusions: Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Annexin A5 / immunology
  • Annexin A5 / physiology
  • Antibodies, Monoclonal / immunology
  • Depressive Disorder / blood*
  • Depressive Disorder / immunology
  • Epitopes / immunology
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Middle Aged
  • Platelet Activation / immunology
  • Platelet Activation / physiology*
  • Platelet Aggregation / immunology
  • Platelet Aggregation / physiology
  • Posture / physiology
  • Rest


  • Annexin A5
  • Antibodies, Monoclonal
  • Epitopes