High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX)

J Med Chem. 1996 Sep 27;39(20):3878-81. doi: 10.1021/jm960502g.

Authors

S S Cha¹, D Lee, J Adams, J T Kurdyla, C S Jones, L A Marshall, B Bolognese, S S Abdel-Meguid, B H Oh

Affiliation

¹ Department of Life Science, Pohang University of Science and Technology, Kyungbuk, South Korea.

PMID: 8831753
DOI: 10.1021/jm960502g

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal
Benzhydryl Compounds / chemistry*
Benzhydryl Compounds / metabolism*
Benzhydryl Compounds / therapeutic use
Chemical Phenomena
Chemistry, Physical
Crystallization
Crystallography, X-Ray*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / metabolism*
Humans
Hydrogen Bonding
Mice
Models, Molecular
Otitis / drug therapy
Phospholipases A / antagonists & inhibitors*
Phospholipases A / chemistry
Phospholipases A / metabolism*
Phospholipases A2
gamma-Aminobutyric Acid / analogs & derivatives*
gamma-Aminobutyric Acid / chemistry
gamma-Aminobutyric Acid / metabolism
gamma-Aminobutyric Acid / therapeutic use

Substances

Anti-Inflammatory Agents, Non-Steroidal
Benzhydryl Compounds
Enzyme Inhibitors
FPL 67047XX
gamma-Aminobutyric Acid
Phospholipases A
Phospholipases A2