Increased hippocampal acetylcholine release during a working memory task

Eur J Pharmacol. 1996 Jun 27;307(2):R1-2. doi: 10.1016/0014-2999(96)00289-0.


In this study we examined whether the food-reinforced alternation performance was associated with increased acetylcholine output in the dorsal hippocampus. Rats were trained to acquire the task using a T-maze. The control group consisted of rats introduced into the T-maze to run only on the day of dialysis. Acetylcholine release increased significantly in control rats only in the first 10 min after they were put into the T-maze. In trained rats acetylcholine output increased in the waiting cage as well as during trials in the T-maze. The increase in acetylcholine output in rats that had learned the task was significantly greater than in control rats.

MeSH terms

  • Acetylcholine / analysis
  • Acetylcholine / metabolism*
  • Animals
  • Chromatography, High Pressure Liquid
  • Hippocampus / chemistry
  • Hippocampus / metabolism*
  • Male
  • Maze Learning / physiology*
  • Memory / physiology*
  • Microdialysis
  • Rats
  • Rats, Sprague-Dawley
  • Reinforcement, Psychology


  • Acetylcholine