A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

Nucl Med Biol. 1996 May;23(4):525-32. doi: 10.1016/0969-8051(96)00036-4.


A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Dose-Response Relationship, Radiation
  • Humans
  • Mathematical Computing
  • Models, Biological*
  • Radioimmunodetection / methods*
  • Radioimmunotherapy / methods*
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Software