Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization

Genomics. 1996 Mar 1;32(2):272-6. doi: 10.1006/geno.1996.0115.


We have isolated a 3.3-kb DNA containing the two exons and a 2.6-kb intron of the human CPX2 gene. This gene encodes the intestinal isoenzyme of glutathione peroxidase, GSHPx-GI. Consistent signals were detected at 14q24.1 when this DNA was used as a probe for fluorescence in situ hybridization on metaphase chromosomes. Based on either single-stranded conformation polymorphism or sequencing analysis, two sites containing DNA polymorphism were found in the intron: the 5' end had a single A/T alteration, and the 3' end had a microsatellite of TC repeats.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 14*
  • DNA
  • Glutathione Peroxidase / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Isoenzymes / genetics*
  • Molecular Sequence Data
  • Polymorphism, Single-Stranded Conformational*


  • Isoenzymes
  • DNA
  • Glutathione Peroxidase

Associated data

  • GENBANK/X91863