Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease

Acta Neuropathol. 1996;91(3):226-35. doi: 10.1007/s004010050420.


In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actin Cytoskeleton / pathology*
  • Actin Cytoskeleton / ultrastructure
  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Protein Precursor / metabolism
  • Amyloid beta-Protein Precursor / ultrastructure
  • Axonal Transport*
  • Humans
  • Immunohistochemistry
  • Microscopy, Immunoelectron
  • Middle Aged
  • Neurites / pathology*
  • Neurites / ultrastructure
  • Neurofibrillary Tangles / pathology*
  • Neurofibrillary Tangles / ultrastructure


  • Amyloid beta-Protein Precursor