Aminopyridine-induced seizure activity

Electroencephalogr Clin Neurophysiol. 1979 May;46(5):605-8. doi: 10.1016/0013-4694(79)90014-2.

Abstract

Typical seizure activity can be induced by applying 3-aminopyridine to the surface of the cat cortex. The well known characteristics of epileptiform discharges were readily observed by simultaneous recording from both the surface and deeper layers.

MeSH terms

  • Aminopyridines*
  • Animals
  • Calcium / metabolism*
  • Cats
  • Electroencephalography
  • Epilepsy / chemically induced
  • Epilepsy / metabolism*
  • Epilepsy / physiopathology
  • Potassium / metabolism*

Substances

  • Aminopyridines
  • Potassium
  • Calcium