Persistence of enthesopathic changes in patients with spondylarthropathy during a 6-month follow-up

Clin Exp Rheumatol. 1995 Nov-Dec;13(6):733-6.


The persistence of enthesopathic changes was studied by ultrasound (US) in 23 patients with spondylarthropathy during a 6-month prospective trial with sulphasalazine (Salazopyrin). During the follow-up significant improvement was seen in the joint symptoms and in the laboratory variables. By US 78% of the patients had enthesopathy at entry and 74% after 6 months of follow-up. The plantar fascia was the enthesis most frequently affected. Treatment with sulphasalazine had no obvious influence on the persistence of enthesopathy. Enthesopathy is as a rule a constant phenomenon and is probably caused by chronic enthesitis. A parallel resolution of anatomic soft tissue changes and the clinical status was not seen on US. There was also no evidence of a favourable effect of sulphasalazine on enthesopathy in the 6-month follow-up.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antirheumatic Agents / therapeutic use
  • Calcaneus / diagnostic imaging
  • Calcaneus / pathology
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Inflammation / pathology
  • Joints / diagnostic imaging
  • Male
  • Middle Aged
  • Spondylitis, Ankylosing / diagnostic imaging*
  • Spondylitis, Ankylosing / drug therapy
  • Sulfasalazine / therapeutic use
  • Tendons / diagnostic imaging*
  • Ultrasonography


  • Antirheumatic Agents
  • Sulfasalazine