Skeletal muscle pathology in systemic sclerosis

J Rheumatol. 1995 Dec;22(12):2246-9.


Objective: Systemic sclerosis (SSc) is characterized by abnormal deposition of collagen in the skin and by visceral involvement. Muscle weakness is a relatively frequent complication of SSc, although severity varies. We studied muscle pathology in patients with SSc with progressive muscle involvement.

Methods: We performed histochemical and immunohistochemical investigations to detect neural cell adhesion molecule (NCAM).

Results: Five of the 6 cases of SSc expressed NCAM in atrophic angulated fibers (some fibers stained heavily with oxidative enzymes).

Conclusion: Neurogenic involvement in SSc is more frequent than reported.

MeSH terms

  • Adolescent
  • Adult
  • Atrophy
  • Biopsy
  • Cell Membrane / chemistry
  • Child
  • Cytoplasm / chemistry
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Muscle Fibers, Skeletal / pathology
  • Muscle, Skeletal / pathology*
  • Necrosis
  • Neural Cell Adhesion Molecules / analysis*
  • Scleroderma, Systemic / pathology*


  • Neural Cell Adhesion Molecules