Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate

J Rheumatol. 1995 Dec;22(12):2359-60.


A 66-year-old woman with longstanding psoriasis involving the skin presented with asymmetrical polyarthritis. Methotrexate (MTX) was given initially intramuscularly and orally. Intramuscular MTX was discontinued, and a few months after she had been taking only oral MTX she developed nodules, first in surgical incisions, and subsequently in her buttocks, thighs, legs, and arms. Reduction of the dose of oral MTX was followed by gradual diminution in size of the nodules and then total disappearance.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Antirheumatic Agents / adverse effects*
  • Arthritis, Psoriatic / chemically induced*
  • Female
  • Humans
  • Injections, Intramuscular
  • Methotrexate / adverse effects*
  • Psoriasis / drug therapy*
  • Rheumatic Nodule / chemically induced*


  • Antirheumatic Agents
  • Methotrexate