Effectiveness of yohimbine in the treatment of erectile disorder: four meta-analytic integrations

Arch Sex Behav. 1996 Aug;25(4):341-60. doi: 10.1007/BF02437578.


The results of four independent yet convergent meta-analyses to examine the efficacy of yohimbine in the treatment of erectile disorder are reported. These meta-analyses integrated data from (i) controlled clinical trials of yohimbine (when used alone), (ii) uncontrolled trials examining yohimbine (alone), (iii) controlled trials of yohimbine when used in combination with other drugs, and (iv) uncontrolled trials of yohimbine plus other drugs. Results document a consistent tendency for yohimbine, and for other medications containing yohimbine, to enhance erectile functioning relative to placebo. We also identify methodological and reporting difficulties that characterize much of the literature.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / administration & dosage
  • Alkaloids / pharmacology*
  • Alkaloids / therapeutic use*
  • Humans
  • Male
  • Penile Erection / drug effects*
  • Sexual Dysfunctions, Psychological / drug therapy*
  • Yohimbine / administration & dosage
  • Yohimbine / pharmacology*
  • Yohimbine / therapeutic use*


  • Alkaloids
  • Yohimbine