Gastric Malt Lymphoma With Crystalline Immunoglobulin Inclusions and Secondary Immunoblastic Lymphoma in a Cervical Lymph Node

Pathol Res Pract. 1995 Oct;191(10):1053-8. doi: 10.1016/s0344-0338(11)80610-2.


A case of gastric B cell lymphoma of the mucosa-associated lymphoid tissue (MALT) with crystalline immunoglobulin inclusions in monotypic plasma cells is reported, which initially presented as a secondary immunoblastic lymphoma in a cervical lymph node. The low-grade MALT lymphoma was diagnosed 14 months after detection of the nodal high-grade lymphoma, but rare crystal-containing plasma cells of identical immunoglobulin isotype found in the immunoblastic lymphoma retrospectively confirmed a common clonal origin. The diagnostic significance of crystalline immunoglobulin inclusions and the unusual initial presentation of MALT lymphoma as a secondary high-grade lymphoma at a distant nodal site are discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Diagnosis, Differential
  • Humans
  • Immunoglobulins / analysis*
  • Inclusion Bodies / pathology*
  • Lymph Nodes / pathology
  • Lymphatic Metastasis
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / surgery
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Male
  • Neck
  • Plasma Cells / pathology
  • Retrospective Studies
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Stomach Ulcer / pathology


  • Immunoglobulins