Selective bilateral lesion of the globus pallidus: ten-year follow-up of memory impairment and frontal symptomatology

Ital J Neurol Sci. 1995 Dec;16(9):635-40. doi: 10.1007/BF02230914.


A case of loss of psychic self-activation (LPSA) and serious amnesia, followed for a period of ten years, is reported. MRI examination documents a selective bilateral lesion of the globus pallidus. This clinical picture, which evokes a cognitive and behavioral deficit of frontal lobe lesions, is attributed to a dysfunction of the frontal cortical area as a result of the breakdown of the frontostriatal circuits.

Publication types

  • Case Reports

MeSH terms

  • Basal Ganglia Diseases / pathology
  • Basal Ganglia Diseases / physiopathology*
  • Basal Ganglia Diseases / psychology*
  • Female
  • Follow-Up Studies
  • Frontal Lobe / physiopathology*
  • Globus Pallidus / pathology
  • Globus Pallidus / physiopathology*
  • Humans
  • Magnetic Resonance Imaging
  • Memory Disorders / psychology*
  • Middle Aged
  • Motivation
  • Neuropsychological Tests