Glutathione conjugation of alkylating cytostatic drugs with a nitrogen mustard group and the role of glutathione S-transferases

Chem Res Toxicol. 1996 Mar;9(2):351-60. doi: 10.1021/tx950143c.

Authors

H A Dirven¹, B van Ommen, P J van Bladeren

Affiliation

¹ Division of Toxicology, TNO Nutrition and Food Research Institute, Netherlands.

PMID: 8839035
DOI: 10.1021/tx950143c

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents, Alkylating / pharmacokinetics*
Biotransformation
Glutathione / metabolism*
Glutathione Transferase / physiology*
Humans
Mechlorethamine / pharmacokinetics*

Substances

Antineoplastic Agents, Alkylating
Mechlorethamine
Glutathione Transferase
Glutathione