Effects of transforming growth factor beta 1 in the hair cycle

J Dermatol. 1996 Feb;23(2):89-94. doi: 10.1111/j.1346-8138.1996.tb03976.x.

Abstract

Hair follicle growth is thought to be regulated by a complex interplay of stimulatory and inhibitory signals. From among such signals, we examined the effects of transforming growth factor beta 1 (TGF beta 1) on the murine hair growth cycle. Quantitation of TGF beta 1 per wet tissue weight was performed at different stages of the hair cycle. TGF beta 1 was extracted with 10 mM HCl, and its level was measured with ELISA. The level of TGF beta 1 did not change markedly during the hair cycle. Immunohistochemical observations revealed that hair follicle cells and epidermal cells were negative for TGF beta 1 at all stages of the hair cycle. Mast cells in the dermis were positive throughout the cycle. To confirm whether the proliferation of hair follicles. Our observations suggest that TGF beta 1 is at least partly responsible for regulating hair follicles as a negative growth factor.

MeSH terms

  • Animals
  • Enzyme-Linked Immunosorbent Assay
  • Hair Follicle / drug effects*
  • Hair Follicle / growth & development
  • Immunohistochemistry
  • Mast Cells / metabolism*
  • Mice
  • Mice, Inbred Strains
  • Transforming Growth Factor beta / metabolism*
  • Transforming Growth Factor beta / pharmacology

Substances

  • Transforming Growth Factor beta