Gene-marking and haemopoietic stem-cell transplantation

Blood Rev. 1995 Dec;9(4):220-5. doi: 10.1016/s0268-960x(95)90013-6.


Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adoptive Transfer
  • Gene Transfer Techniques
  • Genetic Markers*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Lymphoproliferative Disorders / prevention & control*
  • Lymphoproliferative Disorders / virology
  • Monitoring, Physiologic / methods
  • Risk Factors
  • Transplantation, Homologous


  • Genetic Markers