The successful treatment of a gender dysphoric patient with pimozide

Aust N Z J Psychiatry. 1996 Jun;30(3):422-5. doi: 10.3109/00048679609065010.


Objective: The case is reported of a gender dysphoric patient who responded successfully to pharmacotherapy with pimozide.

Clinical picture: An adult male patient with a borderline learning disability presented with cross-dressing and a strong wish to undergo a sex change.

Treatment: Supportive psychotherapy and pharmacotherapy with pimozide was tried.

Outcome: There was an excellent response to pimozide 2 mg daily, with a cessation of both cross-dressing and the wish for sex reassignment. When, after 1 year, the dose was reduced to 1 mg daily, there was a rapid return of the cross-dressing and the wish for sex reassignment. An increase in the dose again led to a remission which has been maintained since then.

Conclusion: Pharmacotherapy with pimozide should be considered in cases of doubtful gender dysphoria.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / adverse effects
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Gender Identity
  • Humans
  • Male
  • Pimozide / administration & dosage*
  • Pimozide / adverse effects
  • Transsexualism / diagnosis
  • Transsexualism / drug therapy*
  • Transsexualism / psychology


  • Antipsychotic Agents
  • Pimozide