Itraconazole in the treatment of orbital aspergillosis

Ophthalmology. 1996 Sep;103(9):1467-70. doi: 10.1016/s0161-6420(96)30482-x.


Background: Sino-orbital aspergillosis is typically treated with surgical debridement and intravenous amphotericin B. Some authors have advocated intraorbital irrigation or injection of amphotericin B in specific cases.

Methods: An immunocompetent patient with recurrent sino-orbital aspergillosis is presented. After failing two attempts at traditional therapeutic modalities, treatment with oral itraconazole was initiated.

Results: The patient has had resolution of her sino-orbital disease without recurrence at 10 months of follow-up.

Conclusion: In immunocompetent patients with orbital aspergillosis, itraconazole should be considered as a treatment option in patients who have recurrent or recalcitrant disease, or in those who cannot tolerate amphotericin B.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy*
  • Aspergillosis / pathology
  • Aspergillus fumigatus / isolation & purification
  • Eye Infections, Fungal / drug therapy*
  • Eye Infections, Fungal / pathology
  • Female
  • Humans
  • Immunocompromised Host
  • Itraconazole / therapeutic use*
  • Magnetic Resonance Imaging
  • Orbit / microbiology
  • Orbital Diseases / drug therapy*
  • Orbital Diseases / microbiology*
  • Orbital Diseases / pathology
  • Recurrence


  • Antifungal Agents
  • Itraconazole