An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study

Stat Med. 1996 Jul 15;15(13):1421-34. doi: 10.1002/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H.


This paper considers an index to assess the success of blinding with application to a clinical trial of disulfiram. The index increases as the success of blinding increases, accounts for uncertain responses, and is scaled to an interval of 0.0 to 1.0, 0.0 being complete lack of blinding and 1.0 being complete blinding.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alcohol Deterrents / therapeutic use
  • Alcoholism / drug therapy
  • Bias
  • Disulfiram / therapeutic use
  • Double-Blind Method*
  • Hospitals, Veterans
  • Humans
  • Multicenter Studies as Topic / standards*
  • Randomized Controlled Trials as Topic / standards*
  • Reproducibility of Results
  • Research Design / standards*


  • Alcohol Deterrents
  • Disulfiram