Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients

Am J Drug Alcohol Abuse. 1996 Aug;22(3):377-88. doi: 10.3109/00952999609001666.


We assessed cocaine abstinence symptomatology in a sample of 100 cocaine-abusing, methadone-maintained patients who completed an anonymous questionnaire retrospectively rating the intensity of 18 symptoms at six time points, from 30 minutes to 2 weeks, post-cocaine use. We found that a majority of patients endorsed symptoms related to dysphoria 24 hours post-binge. However, these symptoms tended to be mild to moderate in intensity and relatively short-lived. Principal components analyses extracted four factors accounting for 64% of the variance: psychoticism, exhaustion, agitation, recovery. Early post-binge period was dominated by psychoticism and agitation, followed by recovery for the duration of the period assessed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Chronic Disease
  • Cocaine*
  • Ethanol
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use*
  • Substance Withdrawal Syndrome / psychology
  • Substance-Related Disorders / drug therapy*
  • Substance-Related Disorders / psychology
  • Time Factors


  • Ethanol
  • Cocaine
  • Methadone