1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors

Ann Biomed Eng. Jul-Aug 1996;24(4):457-73. doi: 10.1007/BF02648108.


To reach cancer cells in a tumor, a blood-borne therapeutic agent must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then to integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Blood Flow Velocity
  • Capillary Permeability
  • Cell Adhesion
  • Cell Movement
  • Humans
  • Microcirculation
  • Models, Biological
  • Neoplasms, Experimental / diagnosis
  • Neoplasms, Experimental / physiopathology*
  • Neoplasms, Experimental / therapy
  • Neovascularization, Pathologic / physiopathology