The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion

Brain Res. 1996 Jul 15;727(1-2):225-9. doi: 10.1016/0006-8993(96)00476-3.

Abstract

An unbiased conditioned place preference procedure was used to determine whether the newly-identified neuropeptide orphanin FQ produced motivational effects after intracerebroventricular microinjections. Microinjections of orphanin FQ (0.1-100 nmol) failed to produce conditioned place preference or aversion, but a pronounced motor impairment was observed during conditioning sessions with the two highest doses. Thus, it appears that orphanin FQ lacks motivational effects when administered at behaviourally active doses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology*
  • Conditioning, Operant / drug effects
  • Conditioning, Operant / physiology*
  • Dose-Response Relationship, Drug
  • Injections, Intraventricular
  • Male
  • Microinjections
  • Morphine / pharmacology
  • Motivation
  • Motor Activity / drug effects
  • Naloxone / pharmacology
  • Narcotic Antagonists
  • Opioid Peptides / administration & dosage
  • Opioid Peptides / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Narcotic Antagonists
  • Opioid Peptides
  • Naloxone
  • Morphine
  • nociceptin