What is the concentration of calcium ions in the endoplasmic reticulum?

Cell Calcium. 1996 Jun;19(6):547-51. doi: 10.1016/s0143-4160(96)90064-0.


Consideration of the data from a number of sources indicates that the concentration of Ca2+ in the endoplasmic reticulum is very high and perhaps in the mM range. A number of implications flow from this-an important one being that the magnitude of Ca2+ gradients across the endoplasmic and plasma membranes are very similar.

Publication types

  • Review

MeSH terms

  • Calcium / analysis*
  • Calcium / metabolism
  • Cell Compartmentation
  • Cytosol / chemistry
  • Endoplasmic Reticulum / chemistry*
  • Osmolar Concentration
  • Signal Transduction


  • Calcium