In vivo MR imaging and spectroscopy using hyperpolarized 129Xe

Magn Reson Med. 1996 Aug;36(2):183-91. doi: 10.1002/mrm.1910360203.

Abstract

Hyperpolarized 129Xe has been used to obtain gas phase images of mouse lung in vivo, showing distinct ventilation variation as a function of the breathing cycle. Spectra of 129Xe in the thorax show complex structure in both the gas phase (-4 to 3 ppm) and tissue-dissolved (190-205 ppm) regions. The alveolar gas peak shows correlated intensity and frequency oscillations, both attributable to changes in lung volume during breathing. The two major dissolved peaks near 195-200 ppm are attributed to lung parenchyma and to blood; they reach maximum intensity in 5-10 s and decay with an apparent T1 of 30 s. Another peak at 190 ppm takes 20-30 s to reach maximum; this must represent other well-vascularized tissue (e.g., heart and other muscles) in the thorax. The maximum integrated area of the tissue components reaches 30-80% of the maximum alveolar gas area, indicating that imaging at tissue frequencies can be achieved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Lung / physiology*
  • Lung Volume Measurements
  • Magnetic Resonance Imaging* / methods
  • Magnetic Resonance Spectroscopy* / instrumentation
  • Magnetic Resonance Spectroscopy* / methods
  • Mice
  • Respiration / physiology*
  • Xenon Isotopes

Substances

  • Xenon Isotopes