Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging

Magn Reson Med. 1996 Aug;36(2):225-31. doi: 10.1002/mrm.1910360209.

Abstract

A noninvasive method using an inversion recovery turbo-FLASH for dynamic measurement of the arterial input function represented by the bolus passage of Gd-DTPA in the descending aorta is presented, and the results are compared with the input function obtained by arterial blood samples. A good accordance between the two input functions was found, indicating that it is possible to measure the input function to the myocardium using MRI. A variation between the two concentration curves of 5% at upslope, 2.7% at peak point, and < 7% at downslope was found. The study also indicates that a short inversion time < 250 ms has to be used to ensure correct measurement of peak concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aorta, Thoracic
  • Arteries
  • Contrast Media / analysis*
  • Gadolinium / blood*
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging*
  • Organometallic Compounds / analysis*
  • Pentetic Acid / analogs & derivatives*
  • Pentetic Acid / analysis
  • Phantoms, Imaging

Substances

  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA