Inorganic fluoride concentration after long-term sedation with isoflurane

Intensive Care Med. 1996 Jul;22(7):677-82. doi: 10.1007/BF01709746.


We report on five patients in whom long-term sedation with isoflurane for up to 7 days was used successfully. Serum inorganic fluoride concentrations were measured daily. The concentrations ranged from 12 mmol l-1 to 29 mmol l-1. These were well below the described renal toxic level of 50 mmol l-1. There was no deterioration in renal function attributable to the use of isoflurane.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Conscious Sedation* / adverse effects
  • Conscious Sedation* / methods
  • Drug Monitoring
  • Fluorides / blood*
  • Humans
  • Isoflurane / therapeutic use*
  • Kidney Function Tests
  • Liver Function Tests
  • Male
  • Middle Aged
  • Neurologic Examination
  • Time Factors


  • Isoflurane
  • Fluorides