The effect of SM-8849 on experimental arthritis in mice

Pharmacology. 1996 Jun;52(6):377-86. doi: 10.1159/000139405.


The effect of a novel thiazole derivative, SM-8849, on experimental arthritis in mice was studied and compared to that of prednisolone. SM-8849 and prednisolone reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity (DTH) in arthritic mice, SM-8849 did not affect the production of humoral antibodies to type II collagen. To examine the inhibitory mechanism of SM-8849, the effects on T cell-dependent allergic inflammation were studied. SM-8849 clearly inhibited T cell-dependent reactions including staphylococcal enterotoxin B (SEB)-induced arthritis, SEB-induced CD25 expression on T cells and sheep red blood cell (SRBC)-induced DTH reaction. SM-8849, however, had no effect on the production of humoral antibody forming cells in the spleen of mice immunized with SRBC. These results indicate that inhibition of type II collagen-induced arthritis by SM-8849 is mainly due to the inactivation of T cells that are related to DTH reaction.

Publication types

  • Comparative Study

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antibody Formation
  • Antibody-Producing Cells / immunology
  • Arthritis / drug therapy*
  • Arthritis / immunology
  • Arthritis / pathology
  • Biphenyl Compounds / pharmacology*
  • CD4 Antigens / immunology
  • Cattle
  • Collagen / immunology
  • Disease Models, Animal
  • Enterotoxins / immunology
  • Hypersensitivity, Delayed
  • Immunity, Cellular
  • Immunization
  • Male
  • Mice
  • Mice, Inbred DBA
  • Prednisolone / pharmacology
  • Receptors, Interleukin-2 / immunology
  • Superantigens / immunology
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • Thiazoles / pharmacology*


  • Adjuvants, Immunologic
  • Biphenyl Compounds
  • CD4 Antigens
  • Enterotoxins
  • Receptors, Interleukin-2
  • Superantigens
  • Thiazoles
  • 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole
  • enterotoxin B, staphylococcal
  • Collagen
  • Prednisolone