Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo

Biol Pharm Bull. 1995 Sep;18(9):1305-7. doi: 10.1248/bpb.18.1305.

Abstract

Depudecin, a microbial metabolite containing two epoxide groups, was tested for its anti-angiogenic activity in an in vivo assay system involving the chorioallantoic membrane of growing chick embryo. The microbial metabolite inhibited embryonic angiogenesis in a dose-dependent manner with an ID50 of 320 ng (1.5 nmol) per egg. It also affected the growth of vascular endothelial cells, a key event in the process of angiogenesis in vivo. These results suggest that depudecin could be promising as an anti-angiogenic agent and that its anti-angiogenic action involves an inhibitory effect on vascular endothelial cell growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes / pharmacology*
  • Animals
  • Cell Division / drug effects
  • Chick Embryo
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Epoxy Compounds / pharmacology*
  • Fatty Alcohols / pharmacology*
  • Humans
  • Neovascularization, Physiologic / drug effects*

Substances

  • Alkadienes
  • Epoxy Compounds
  • Fatty Alcohols
  • depudecin