Proton and potassium transport by H+/K(+)-ATPases

Clin Exp Pharmacol Physiol. 1995 Dec;22(12):952-60. doi: 10.1111/j.1440-1681.1995.tb02332.x.


1. H+/K(+)-ATPases are members of the P-type ATPase multigene family. The prototypical H+/K(+)-ATPase is the protein that acidifies gastric luminal contents. The physiological and pharmacological significance of this pump has led to a detailed investigation of its biochemistry and molecular and cell biology. 2. Recently, a number of closely related H+/K(+)-ATPase isoforms have been discovered. These isoforms are present in organs other than the stomach, including the colon and kidney, where they contribute to acid-base and potassium homeostasis. The structure, expression and physiological roles of the gastric H+/K(+)-ATPase and other isoforms are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Colon / metabolism
  • Gastric Mucosa / metabolism
  • H(+)-K(+)-Exchanging ATPase / metabolism
  • H(+)-K(+)-Exchanging ATPase / physiology*
  • Humans
  • Ion Transport
  • Molecular Structure
  • Potassium / metabolism*
  • Protons*


  • Protons
  • H(+)-K(+)-Exchanging ATPase
  • Potassium