Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity

MeSH terms

• Animals
• Bone Marrow / drug effects
• Bone Marrow Cells
• Cell Division / drug effects
• Cell Survival / drug effects*
• Cells, Cultured
• DNA / biosynthesis
• Folic Acid / analogs & derivatives
• Folic Acid / physiology
• Humans
• In Vitro Techniques
• Methotrexate / adverse effects*
• Methotrexate / metabolism
• Osmolar Concentration
• Purine Nucleosides / physiology
• Time Factors